Lynparza approved in the EU for the treatment of BRCA


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1 dag sedan · Metastatic castration-resistant prostate cancer (mCRPC) continues to be a major cause of complications and death among men [1,2,3]. Management of mCRPC is still controversial . Several therapies have been shown to improve the overall survival (OS) and progression-free survival (PFS) of men with mCRPC [4,5,6]. 2018-12-05 · Background Treatment of metastatic prostate cancer is associated with high personal and economic burden. Recently, new treatment options for castration-resistant prostate cancer became available with promising survival advantages.

Castration resistant

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sensitive prostate cancer to castration-resistant disease is still not fully understood, but with recent scientific breakthroughs in basic research, there is now a greater understanding. We now know that despite castrate levels of androgens, the androgen receptor (AR) remains active and … About Metastatic Castration-Resistant Prostate Cancer Metastatic castration-resistant prostate cancer (mCRPC) characterizes cancer that no longer responds to ADT and has spread to other parts of the body. The most common metastatic sites are bones, followed by lymph nodes, lungs, and liver. 2019-02-14 2021-03-21 Non-Metastatic Castration Resistant Prostate Cancer (nmCRPC) Treatment Market Segmentation by Therapy Type (Chemotherapy, Immunotherapy, Radiotherapy, Hormonal Therapy, and Others); and by Application (General Medical & Surgical Hospitals, Speciality Hospitals, Clinics, and Others) – Global Demand Analysis and Opportunity Outlook 2021-2029 Carboplatin added to cabazitaxel showed improved clinical efficacy compared with cabazitaxel alone for men with metastatic castration-resistant prostate cancer. Although adverse events were more common with the combination, the treatment was safe and generally well tolerated. Our data suggest that taxane–platinum combinations have a clinically beneficial role in advanced prostate cancer and BackgroundTo explore the genomic profiles of Chinese patients with castration-sensitive prostate cancer(CSPC) and those with metastatic castration-resistant prostate cancer(mCRPC) via germline and circulating tumor DNA(ctDNA) sequencing.MethodsA hybridization capture-based next-generation sequencing assay was used to identify germline and somatic alterations in 50 genes, including … 1 day ago 2020-02-24 ASCO GU 2021 Genitourinary Cancers Symposium, 177Lu-PSMA-617 Versus Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer Progressing After Docetaxel: Updated Results Including Progression-Free Survival and Patient-Reported Outcomes (TheraP ANZUP 1603).


Single-center, prospective, non controlled, open label, phase II trial. The main objective of this study is to evaluate the Disease Control Rate (DCR) and the safety as co-primary objective. AstraZeneca today announced that the US Food and Drug Administration (FDA) has granted Breakthrough Therapy designation (BTD) for the oral poly ADP-ribose polymerase (PARP) inhibitor Lynparza™ (olaparib), for the monotherapy treatment of BRCA1/2 or ATM gene mutated metastatic Castration Resistant Prostate Cancer (mCRPC) in patients who have received a prior taxane-based chemotherapy and at 2019-07-30 · Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with diverse drivers of disease progression and mechanisms of therapeutic resistance.

Forskningsanslag 2021 Prostatacancerförbundet

Castration resistant

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ODM-204, a Novel Dual Inhibitor of CYP17A1 and Androgen Receptor: Early Results from Phase I Dose Escalation in Men with Castration-resistant Prostate  PSMA-Targeted Radioligand Therapeutic Phase 3 Trial in Patients with Metastatic Castration Resistant Prostate Cancer (Businesswire). Allarity is running a single arm, open label Phase 2 Study of Irofulven for treatment of metastatic castration-resistant prostate cancer in patients who have  PATIENTS AND METHODS: Twenty-eight patients with castration-resistant prostate cancer and confirmed bone metastasis were assigned to seven infusions of  ASCO-GU 2019—Darolutamide improves MFS in castration-resistant prostate cancer. Darolutamide may offer an alternative to apalutamide and enzalutamide.
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Castration resistant

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Registret för kliniska prövningar. ICH GCP. Villkor: Prostatic Neoplasms, Castration-Resistant Drug Use Investigation of Xofigo, Castration Resistant Prostate Cancer With Bone Metastases.
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2014 Aug:21(4):663-75. 5) Salim A, Ma X, Fall K, Andrén O, Reilly M. Analysis of  About castration-resistant prostate cancer (CRPC) Prostate cancer is the second most commonly diagnosed malignancy in men worldwide. Unique well-characterized prostate models derived from castration resistant and hormone sensitive primary tissue now available for studies  of 177LU-PSMA-617 in the treatment of patients with progressive PSMA-positive, metastatic castration-resistant prostate cancer (mCRPC). team at John associated the androgen receptor splice variant 7 with resistance to therapies for metastatic castration-resistant prostate cancer.